This comprehensive reference work presents an up-to-date survey of the current scientific understanding of the metabolic syndrome, as well as an overview of the most significant advances in the field. The book offers a thorough reference for obesity and the metabolic syndrome and will prove an indispensable resource for clinicians, researchers and students. The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on excessive consumption of energy-dense food, sedentary lifestyle, and other behaviors that contribute to the pathogenesis of obesity. However, obesity is a highly complex condition that is influenced by genetic as well as environmental factors. The metabolic syndrome comprises of central obesity, hyperglycemia, hypertension, and dsylipidemia. The incidence of metabolic syndrome is growing worldwide, affecting more than one-third of adults in some countries. The metabolic syndrome increases the risk of developing coronary artery disease and stroke, and it is closely associated with fatty liver, dementia, cancer, sleep apnea, kidney failure, and other diseases. This reference work covers the full range of scientific and clinical aspects of obesity and metabolic syndrome: epidemiology, genetics, environmental factors, pathophysiology, diseases associated with obesity, pediatric obesity, and clinical management.
Table of contents (41 entries)
Front Matter
Pages i-xxvii
Epidemiology
Front Matter
Pages 1-1
Overview of Metabolic Syndrome
Rexford S. Ahima
Pages 3-14
Obesity and Metabolic Syndrome in the United States
Albert Danso Osei, Elise Tirza A. Ohene-Kyei, Justin B. Echouffo-Tcheugui
Pages 15-32
Obesity and Metabolic Syndrome in Latin America
Ana Elena Espinosa de Ycaza, Stanley M. Chen Cardenas
Pages 33-46
Obesity in Africa: A Silent Public Health Crisis
Charles Agyemang, Sandra Boatemaa Kushitor, Grace Frempong Afrifa-Anane, Ama de-Graft Aikins
Pages 47-64
Obesity in Middle East
Zlatko Nikoloski
Pages 65-80
Obesity and Metabolic Syndrome in South Asians
Rajvarun S. Grewal, Alycia Hancock, Angela Yang, Rita R. Kalyani
Pages 81-101
Obesity in East Asia
Yong-Moon Mark Park, Mee Kyoung Kim, Junxiu Liu
Pages 103-121
Genetic Factors
Front Matter
Pages 123-123
Download chapter PDF
Evolution of Obesity
John R. Speakman
Pages 125-143
Genetics of Type 2 Diabetes
Struan F. A. Grant
Pages 145-161
Genetics of Lipid Disorders
Nora L. Nock
Pages 163-195
Environmental Factors
Front Matter
Pages 197-197
Diet and Obesity
Laura E. Matarese
Pages 199-215
The Built Environment and Metabolic Syndrome
Thao Minh Lam, Nicolette R. den Braver, Jeroen Lakerveld
Pages 217-228
Social and Community Networks and Obesity
Houssem Ben Khalfallah, Mariem Jelassi, Narjes Bellamine Ben Saoud, Jacques Demongeot
Pages 229-246
Pathophysiology
Front Matter
Pages 247-247
Download chapter PDF
Principles of Energy Homeostasis
Rexford S. Ahima
Pages 249-266
Carbohydrate, Protein, and Fat Metabolism in Obesity
Jose E. Galgani, Víctor Cortés, Fernando Carrasco
Pages 267-282
Pathophysiology
Brain Regulation of Feeding and Energy Homeostasis
Alison H. Affinati, Carol F. Elias, David P. Olson, Martin G. Myers Jr
Pages 283-301
Adipose Structure (White, Brown, Beige)
Vanessa Pellegrinelli, Antonio Vidal-Puig, Stefania Carobbio
Pages 303-334
Adipokines and Metabolism
Rexford S. Ahima, Hyeong-Kyu Park
Pages 335-356
Gut Hormones and Metabolic Syndrome
Salman Zahoor Bhat, Hyeong-Kyu Park, Rexford S. Ahima
Pages 357-372
Gut Microbiome, Obesity, and Metabolic Syndrome
Herbert Tilg, Alexander R. Moschen
Pages 373-384
Pancreatic Islet Adaptation and Failure in Obesity
Yumi Imai, Dalal El Ladiki, Spencer J. Peachee
Pages 385-404
Insulin Resistance in Obesity
Wanbao Yang, Jeffrey Guo, Shaodong Guo
Pages 405-427
Linking Inflammation, Obesity, and Diabetes
Maeve A. McArdle, Elaine B. Kennedy, Helen M. Roche
Pages 429-448
Circadian Rhythms and Metabolism
Edith Grosbellet, Etienne Challet
Pages 449-471
Obesity, Myokines, and Metabolic Health
Noemi Malandrino, Rexford S. Ahima
Pages 473-489
Body Composition Assessment
Roshan Dinparastisaleh, Sara Atiq Khan, Prasanna Santhanam
Pages 491-505
Diseases Associated with Obesity
Front Matter
Pages 507-507
Download chapter PDF
Type 2 Diabetes: Etiology, Epidemiology, Pathogenesis, and Treatment
Carrie Burns, Nnenia Francis
Pages 509-528
Dyslipidemia in Metabolic Syndrome
Sue-Anne Toh, Michelle H. Lee
Pages 529-546
Obesity and Cardiovascular Disease
Martin A. Alpert, Carl J. Lavie, Natraj Katta
Pages 547-565
Non-alcoholic Fatty Liver Disease
Sangwon F. Kim, Jang Hyun Choi
Pages 567-583
Sarcopenic Obesity
Danae C. Gross, Ray Cheever, John A. Batsis
Pages 585-602
Linking Obesity, Metabolism, and Cancer
Ivana Vucenik, Laundette P. Jones, John C. McLenithan
Pages 603-620
Endocrine Disorders Associated with Obesity
Hyeong-Kyu Park, Rexford S. Ahima
Pages 621-637
Obesity, Metabolic Syndrome, and Sleep Disorders
Daisy Duan, Jonathan C. Jun
Pages 639-658
Diseases Associated with Obesity
Connecting Obesity and Reproductive Disorders
Rexford S. Ahima, Jenny Pena Dias
Pages 659-674
Metabolic Syndrome and Kidney Diseases
Vincent Boima, Alexander B. Agyekum, Augustus K. Eduafo
Pages 675-691
Prevention and Treatment
Front Matter
Pages 693-693
Download chapter PDF
Diet, Exercise, and Behavior Therapy
Leah M. Schumacher, David B. Sarwer, Kelly C. Allison
Pages 695-712
Pharmacotherapy of Obesity and Metabolic Syndrome
Daisy Duan, Rexford S. Ahima
Pages 713-737
Bariatric Surgery
Rexford S. Ahima, Hyeong-Kyu Park
Pages 739-756
Prevention and Treatment of Obesity in Children
Talia A. Hitt, Katie L. Wasserstein, Sara N. Malina, Sheela N. Magge
Pages 757-783
Global, National, and Community Obesity Prevention Programs
Regien Biesma, Mark Hanson
Pages 785-799
Back Matter
Pages 801-815
About the Author
Rexford S. Ahima is a Professor of Medicine, Public Health, and Nursing, Bloomberg Distinguished Professor of Diabetes, and director of the Division of Endocrinology, Diabetes and Metabolism at the Johns Hopkins University. He received his medical degree from the University of Ghana, and a Ph.D. in Neuroscience from Tulane University in New Orleans, Louisiana. He did his internship and residency training in Internal Medicine at the Jacobi Medical Center and Weiler Hospital, Albert Einstein College of Medicine, in the Bronx, New York, and clinical and research fellowship in Endocrinology, Diabetes and Metabolism at the Beth Israel Deaconess Medical Center and Harvard Medical School in Boston. Dr. Ahima has been elected to the National Academy of Medicine, American Academy of Arts and Sciences, American Association for the Advancement of Science, American Society for Clinical Investigation, Association of American Physicians, American College of Physicians, Interurban ClinicalClub, and the Obesity Society. He is a former editJournal of Clinical Investigation, and associate editor of Gastroenterology, Molecular Endocrinology, and Endocrine Reviews. Dr. Ahima has served on various committees of the National Institutes of Health, the Endocrine Society, and other health and scholarly organizations. His research is focused on central and peripheral regulation of energy homeostasis and the pathophysiology of obesity, diabetes and related diseases. He is board certified in Endocrinology, Diabetes and Metabolism, and is the leader of the Johns Hopkins Diabetes Initiative.
