Description
With the widespread adoption of checkpoint inhibitors as standard-of-care therapy for many cancers, the associated toxicities affecting multiple organ systems have become a significant limiting factor, particularly in select patient populations. Some organ-specific toxicities can be severe and life-threatening. Early recognition and prompt, effective management of these conditions are critical to improving patient care and ensuring the continued delivery of cancer therapy over the long term.
Designed as a companion volume to our first handbook Managing Immunotherapy-Related Organ Toxicities published in 2022, this new book presents 65 unique and challenging cases involving toxicities across more than ten different organ systems. Each case includes a detailed clinical presentation, evaluation, treatment approach, and long-term patient outcome. The contributors are a group of leading experts from 14 centers worldwide, all of whom provide routine care for patients with complex toxicity conditions.
This is the first book of its kind, Challenging Cases of Immunotherapy-Related Organ Toxicities, highlighting the real-world challenges physicians encounter in oncology clinical practice.
Table of contents (56 chapters)
Front Matter
Pages i-xiv
Cardiology
Front Matter
Pages 1-1
Download chapter PDF
Complete Heart Block and Myocarditis Related to Immune Checkpoint Inhibitor Therapy
Noah Beinart, Nicolas L. Palaskas
Pages 3-8
Dermatology
Front Matter
Pages 9-9
Download chapter PDF
Bullous Pemphigoid Post Immune Checkpoint Inhibitor Therapy
Hannah Y. Wang, Phyu Aung, Anisha B. Patel
Pages 11-20
Erosive Oral Lichen Planus with Pemphigus Vulgaris Post Immune Checkpoint Inhibitor Treatment
Hannah Y. Wang, Carlos A. Torres-Cabala, Anisha B. Patel
Pages 21-32
Dermatomyositis Post Immune Checkpoint Inhibitor Therapy
Rishabh Lohray, Anisha B. Patel
Pages 33-42
Rapid Resolution of Refractory Immunotherapy-Related Transient Acantholytic Dermatosis with Dupilumab
Melissa R. Laughter, Ata S. Moshiri
Pages 43-47
Endocrinology
Front Matter
Pages 49-49
Download chapter PDF
Hypophysitis Post Immune Checkpoint Inhibitor Therapy
Sean Ngo, Jeena Varghese
Pages 51-56
Graves’ Disease After Prolonged Immune Checkpoint Inhibitor Therapy
Janki Patel, Conor Best
Pages 57-61
Worsening Hyperglycemia During Immune Checkpoint Inhibitor Therapy
Irene J. Lee, Kei Takigawa, Conor Best
Pages 63-67
Lipodystrophy after Receiving Immune Checkpoint Inhibitor Therapy
Nina Semsarzadeh, Pradnya D. Patil, Kord Honda, Joshua Arbesman, Pauline Funchain
Pages 69-74
Hypoglycemia Secondary to Anti-PD-1 Therapy
Skyler Burke, Evan Ong, Adam Bograd, Laura Bovee, Kelly G. Paulson
Pages 75-79
Transient Diabetes Insipidus Related to Immune Checkpoint Inhibitor Therapy
Anna Olsson-Brown
Pages 81-86
Gastroenterology
Front Matter
Pages 87-87
Download chapter PDF
Appendicitis Post Immune Checkpoint Inhibitor Therapy
Antony Mathew, Yang Lu, Malek Shatila, Nizar M. Tannir, Bilal Siddiqui, Yinghong Wang
Pages 89-94
Cholecystitis Related to Immune Checkpoint Inhibitor Therapy
Malek Shatila, Krishnavathana Varatharajalu, Gottumukkala Subba Raju, Anusha S. Thomas, Yinghong Wang
Pages 95-101
Colitis Following Immune Checkpoint Inhibitor Therapy
Malek Shatila, Krishnavathana Varatharajalu, Herbert Dupont, Robert Jenq, Franck Carbonnel, Stephen Hanauer et al.
Pages 103-111
CMV Colitis with Perforation Post Immune Checkpoint Inhibitor Therapy with Multi-Organ Failure
Nitish Mittal, Christine Catinis, Yang Lu, Swaminathan Padmanabhan Iyer, Pablo C. Okhuysen, Yinghong Wang
Pages 113-118
Gastroenterology
Diverticulitis Post Immune Checkpoint Inhibitor Therapy
Austin R. Thomas, Yang Lu, Karen Amelia Nahmod, Dongfeng Tan, Mehmet Altan, Mehnaz A. Shafi et al.
Pages 119-124
Enteritis and Venous Thromboembolism Related to Immune Checkpoint Inhibitor Therapy
Sidra Naz, Yang Lu, Anusha S. Thomas, Yinghong Wang
Pages 125-129
Stomach Perforation Post Immune Checkpoint Inhibitors Treatment
Antonio Pizuorno Machado, Yang Lu, Yinghong Wang
Pages 131-134
Sclerosing Mesenteritis After Immune Checkpoint Inhibitor Therapy
Andrew G. Kuang, Yang Lu, Dongfeng Tan, Malek Shatila, John A. Thompson, Yinghong Wang
Pages 135-141
Pneumatosis Intestinalis Following Immune Checkpoint Inhibitor Therapy
Gabriel Sperling, Yang Lu, Malek Shatila, Krishnavathana Varatharajalu, Bryan Schneider, Anam Khan et al.
Pages 143-148
Pouchitis Post Immune Checkpoint Inhibitor Therapy
Gabriel Sperling, Malek Shatila, Dan Zhao, Yan Zhou, Yinghong Wang
Pages 149-157
Rectal Ulcer and Perianal Fistula in a Cancer Patient on Immune Checkpoint Inhibitor Therapy
Christine Catinis, Nitish Mittal, Maya Sarihan, Abdullah Aleem, Jianbo Wang, Matthew T. Campbell et al.
Pages 159-165
Recurrent Clostridioides Difficile Infection and Colitis Post Immune Checkpoint Inhibitor Therapy
Elliot Baerman, Kristin Junek, Rey Cerbas Lavilla, Xin Shelley Wang, Yinghong Wang
Pages 167-172
Immune Related Toxicities in Multiple Organs in a Patient with Preexisting Autoimmune Disease
Alice Saji, Omar Alhalabi, Shailender Bhatia, Yinghong Wang
Pages 173-177
Upper Gastrointestinal Toxicity Following Immune Checkpoint Inhibitor Therapy
Malek Shatila, Krishnavathana Varatharajalu, Mehnaz A. Shafi, Anusha S. Thomas, Yinghong Wang
Pages 179-185
Immune Checkpoint Inhibitor Use in Patients with Pre-Existing Inflammatory Bowel Disease
David M. Faleck, Amitabh Srivastava, Juliana Eng
Pages 187-195
Gastroparesis and Gastrointestinal Motility Dysfunction Following Immune Checkpoint Inhibitor Therapy
Matthew J. Townsend, Shilpa Grover
Pages 197-203
Celiac Disease in the Setting of Immune Checkpoint Inhibitor Therapy
Ayo Falade, Yousef Badran, Michael Dougan
Pages 205-209
Non-Celiac Enteropathy Post Immune Checkpoint Inhibitor Therapy
Jessica El Halabi, Jessica Philpott
Pages 211-215
Refractory Immune Checkpoint Inhibitor (ICI)-Mediated Colitis
Joseph Sleiman, Rhonda M. Brand, Reetesh Pai, Randall E. Brand, John Rhee, Marc Schwartz et al.
Pages 217-224
Hematology
Front Matter
Pages 225-225
Download chapter PDF
Autoimmune Hemolytic Anemia Post Immune Checkpoint Inhibitors
Blessie Elizabeth Nelson, Thein Hlaing Oo, Cristhiam Rojas-Hernandez
Pages 227-234
Immune Thrombocytopenic Purpura Post Immune Checkpoint Inhibitor Therapy
Thein Hlaing Oo, Francisco Vega, Cristhiam Rojas-Hernandez
Pages 235-239
Hepatology
Front Matter
Pages 241-241
Hepatobiliary Toxicity Secondary to Immune Checkpoint Inhibitor Therapy: Early Tocilizumab Treatment to Decouple Steroid Dependency
Hao Chi Zhang, Sean Ngo, Deyali Chatterjee, Ethan Miller, Amado J. Zurita, Lan Wang
Pages 243-255
Hepatology
Cholangiohepatitis with Extrahepatic Cholangiopathy and Cholecystitis Secondary to Immune Checkpoint Inhibitor Therapy
Hao Chi Zhang, Andres Urias Rivera, Ethan Miller, Yun Shin Chun, Celia Robinson Ledet, Lan Wang
Pages 257-265
Immune Checkpoint Inhibitor-Mediated Hepatotoxicity: Personalized Management Based on Evolving Biochemical Behaviors
Hao Chi Zhang, Jay Shah, Asif Rashid, Ethan Miller, Pavlos Msaouel, Lan Wang
Pages 267-276
Use of Immune Checkpoint Inhibitors Prior to and After Liver Transplantation
Alexander Philipp, Daniel Rössler, Helga Török, Christian Lange, Enrico De Toni
Pages 277-283
Nephrology
Front Matter
Pages 285-285
Download chapter PDF
Acute Tubulointerstitial Nephritis Post Immune Checkpoint Inhibitor Therapy
Ala Abudayyeh, Jean Tayar, Amanda Tchakarov
Pages 287-292
Vasculitis Post Immune Checkpoint Inhibitors Therapy
Sehrish Qureshi, Naszrin Arani, Maria Suarez-Almazor, Amanda Tchakarov, Mehmet Altan, Ala Abudayyeh
Pages 293-299
Membranous Nephropathy Post Immune Checkpoint Inhibitors
Ala Abudayyeh, Adi Diab, Amanda Tchakarov
Pages 301-305
Neurology
Front Matter
Pages 307-307
Download chapter PDF
Encephalitis/Meningoencephalitis Post Immune Checkpoint Inhibitor Therapy
Sudhakar Tummala
Pages 309-318
Neuromuscular Complications Post Immune Checkpoint Inhibitor Therapy
Sudhakar Tummala
Pages 319-328
Hyperosmia Secondary to Immune Checkpoint Inhibitor Therapy
Jane M. Taylor, Marcus S. Dempster, Jung-Min Song, Lucy Boyce Kennedy, Pauline Funchain
Pages 329-334
Ophthalmology
Front Matter
Pages 335-335
Download chapter PDF
Optic Neuritis Post Immune Checkpoint Inhibitor Therapy
May Ameri, Andrew Whyte, Nagham Al-Zubidi
Pages 337-344
Uveitis Post Immune Checkpoint Inhibitor Therapy
Zachary DeZeeuw, Azadeh Razmandi, Nagham Al-Zubidi
Pages 345-353
Autoimmune Retinopathy Secondary to Nivolumab
Phillip Saikaly, Charles Drescher, Sharel C. Ongchin, Kelly G. Paulson
Pages 355-358
Pancreatology
Front Matter
Pages 359-359
Pancreatitis Related to Immune Checkpoint Inhibitor Therapy
Sidra Naz, Sireesha Yedururi, Yinghong Wang, Suresh Chari, Anusha S. Thomas
Pages 361-367
Necrotizing Pancreatitis Related to Immune Checkpoint Inhibitor Therapy
Sidra Naz, Sireesha Yedururi, Yinghong Wang, Suresh Chari, Anusha S. Thomas
Pages 369-374
Pulmonology
Front Matter
Pages 375-375
Immune Checkpoint Inhibitor Therapy Induced Relapsing Pneumonitis
Saad Farooq, Saadia A. Faiz, Vickie R. Shannon, Ajay Sheshadri
Pages 377-385
Pulmonology
Pneumonitis and COVID-19 Pneumonia Post Immune Checkpoint Inhibitor Therapy
Saad Farooq, Saadia A. Faiz, Vickie R. Shannon, Ajay Sheshadri
Pages 387-396
Immune Checkpoint Inhibitor Associated Pneumonitis in a Patient with Interstitial Lung Abnormalities
Saad Farooq, Saadia A. Faiz, Vickie R. Shannon, Ajay Sheshadri
Pages 397-405
Tracheobronchitis Related to Pembrolizumab Therapy
Shaun Pienkos, Gerald Berry, Kaissa de Boer, Nathaniel Myall
Pages 407-414
Rheumatology
Front Matter
Pages 415-415
Download chapter PDF
Inflammatory Arthritis Post Immune Checkpoint Inhibitor Therapy
Savannah Bowman, Rodabe N. Amaria, Huifang Lu
Pages 417-423
Sicca Syndrome Induced by Immune Checkpoint Inhibitor Therapy
Yuanteng Jeff Li, Sang T. Kim, Nizar M. Tannir, Huifang Lu
Pages 425-431
Polymyalgia Rheumatica-Like Syndrome Post Immune Checkpoint Inhibitor Therapy
Huifang Lu, Savannah Bowman, N. P. Linda Bobby, Sang T. Kim, Pavlos Msaouel, Jean Tayar
Pages 433-438
Large Vessel Vasculitis Occurring After Exposure to Immune Checkpoint Inhibitor Therapy
Joshua O. Hendin, P. Scott Pollock, Pratyusha D. Banik, Scott C. DeRoo, Patricia J. Papadopoulos, Kelly D. Smith et al.
Pages 439-445
Multi-organ Toxicity
Front Matter
Pages 447-447
A Case of Persistent, Delayed Multisystem Toxicities After Anti-PD-1 Therapy
Rachel S. Goodman, Hannah Burnette, Douglas B. Johnson
Pages 449-454
Back Matter
Pages 455-460
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.