This book offers a comprehensive overview on the topic of liver regeneration with the aim of providing a potentially curative surgical treatment for liver tumours. it will be divided into five thematic sessions: from the cellular and haemodynamic mechanisms that act as triggers for the regeneration process, to currently available techniques based on surgical and/or interventional radiology methods, their optimisation and risks, to a discussion of how to use hypertrophy techniques in the context of each specific disease setting and new frontiers. Despite the fact that this is a progressively evolving field, the importance of performing major liver resections in a safe setting - reducing the risk of post-operative liver failure, which is the most serious potentially life-threatening complication in liver surgery - will remain unchanged in the field of cancer surgery. In this scenario, a book providing a systematic discussion of the state of the art and evidence now established in this field is an essential tool for any centre with an active liver surgery programme. The multidisciplinary perspective used to address this topic is a further innovative value of this project, which has the ambition of meeting the need for a lasting cultural background on this subject.
Table of contents (23 chapters)
Front Matter
Pages i-xix
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Liver Regeneration and Liver Failure
Front Matter
Pages 1-1
Mechanisms of Liver Regeneration
Alexander Kofler, Lukas Pölsler, Rupert Oberhuber, Florian Primavesi
Pages 3-37
Microbiota and Liver–Gut Axis in Liver Regeneration
Luigi Colecchia, Giovanni Marasco, Giovanni Barbara
Pages 39-48
Metabolic Factors Affecting Liver Regeneration
Markus Ammann, Patrick Starlinger
Pages 49-67
Pathogenesis of Postoperative Liver Failure
Tim Reese, Karl J. Oldhafer
Pages 69-81
Diagnosis and Classification of Posthepatectomy Liver Failure
Emrullah Birgin, Jan Heil, Nuh N. Rahbari
Pages 83-91
Volumetric and Functional Evaluation of Remnant Liver
Front Matter
Pages 93-93
Volumetric Study of the Liver and Cutoffs for a Safe Liver Surgery
Elena Panettieri, Antony Haddad, Jean-Nicolas Vauthey
Pages 95-103
Functional Study of the Liver: Imaging Tests
Pieter Arntz, Fenna van der Zijden, Thomas Van Gulik, Nienke Wassenaar, Roel Bennink, Joris Erdmann
Pages 105-115
Functional Study of the Liver: Nonimaging Tests
Takashi Kokudo, Norihiro Kokudo
Pages 117-125
Portal Flow and Pressure Modulation in Major Hepatectomies
Goudarz T. Passand, Nicolas Golse
Pages 127-137
Techniques to Induce Liver Hypertrophy
Front Matter
Pages 139-139
Portal Vein Embolization
Yujiro Nishioka, Kiyoshi Hasegawa
Pages 141-154
Portal Vein Ligation
Francesco Ardito, Felice Giuliante
Pages 155-160
Two-Stage Hepatectomy
Katsunori Imai, René Adam
Pages 161-173
ALPPS: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy
Victoria Ardiles, Fernando A. Alvarez, Eduardo de Santibañes
Pages 175-187
Hepatic Deprivation
Fabio Giannone, Gianluca Cassese, Valentina Schembri, Boris Guiu, Fabrizio Panaro
Pages 189-199
Radioembolization
Cristina Mosconi, Alberta Cappelli, Domenico Santangelo, Francesco De Cobelli
Pages 201-217
Liver Hypertrophy in Different Settings of Disease
Front Matter
Pages 219-219
Liver Hypertrophy in Different Settings of Disease
Rationale and Techniques for Liver Hypertrophy in Colorectal Liver Metastases
Ernesto Sparrelid
Pages 221-227
Rationale and Techniques for Liver Hypertrophy in Hepatocellular Carcinoma
Miu-Yee Chan, Albert Chi-Yan Chan
Pages 229-239
Rationale and Techniques for Liver Hypertrophy in Cholangiocarcinoma
Shoji Kawakatsu, Takashi Mizuno, Shunsuke Onoe, Nobuyuki Watanabe, Mihoko Yamada, Tomoki Ebata
Pages 241-248
Rationale and Techniques for Liver Hypertrophy in Transplant Setting
E. Gringeri, A. Marchini, U. Cillo
Pages 249-256
Further Insights
Front Matter
Pages 257-257
Impact of Minimally-Invasive Approaches
Hwee-Leong Tan, Brian K. P. Goh
Pages 259-266
The Dropout Phenomenon in Liver Regeneration
Victor Lopez-Lopez, Asunción Lopez Conesa, Roberto Brusadin, Patricia Pastor, Alvaro Navarro, Ricardo Robles-Campos
Pages 267-280
Management of Postoperative Liver Failure
Gianluca Rompianesi, Roberto Troisi
Pages 281-292
Future of Regenerative Hepatology
Javier Martínez-García, Álvaro Blanes-Rodríguez, Sandra Melitón-Barbancho, Marta Sáinz-Viartola, Pedro M. Baptista
Pages 293-308
